AbstractThis paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problemin medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as otherpedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality andutility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish communityof Lancaster County, Pennsylvania.Many genetic studies require linkage analysis, a key step toward positional cloning of disease susceptibility genes. Linkageanalysis requires describing pedigrees for a set of people exhibiting a specific trait and verifying relationships in pedigrees(; ).
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